Trifluoroacetic acid → HCID 178493992, Verbindung

HRID 1011032Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1011032
[CH3:1][O:2][C:3]1[N:4](C2CCCCO2)[C:5]2[C:10]([N:11]=1)=[C:9]([NH2:12])[N:8]=[C:7]([O:13][CH2:14][CH:15]1[CH2:19][CH2:18][CH2:17][O:16]1)[N:6]=2.[F:26][C:27]([F:32])([F:31])[C:28]([OH:30])=[O:29]>CO>[F:26][C:27]([F:32])([F:31])[C:28]([OH:30])=[O:29].[CH3:1][O:2][C:3]1[NH:4][C:5]2[C:10]([N:11]=1)=[C:9]([NH2:12])[N:8]=[C:7]([O:13][CH2:14][CH:15]1[CH2:19][CH2:18][CH2:17][O:16]1)[N:6]=2

Komponenten

4

Edukt 2

HCID 6422Trifluoroacetic acidHCID 576998158-(Methoxy)-2-[(tetrahydro-2-furanylmethyl)oxy]-9-(tetrahydro-2H-Pyran-2-yl)-9H-purin-6-amine

Produkt 1

HCID 178493992HCID 178493992, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

8-(Methoxy)-2-[(tetrahydro-2-furanyl methyl)oxy]-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-amine (1.1614 g) was dissolved in methanol (20 mL) and treated with neat trifluoroacetic acid (2 mL). The reaction mixture was stirred for 24 hours to give a white suspension. The reaction mixture was then evaporated to dryness under reduced pressure. The resultant white solid was suspended using ethyl acetate (10 mL) and then isolated by filtration, washing with ethyl acetate (2 mL). The solid was air-dried under suction and then dried further under vacuo at 50° C. This gave the title compound as a white solid (1.0602 g).

Aufarbeitung

  1. customto give a white suspension
  2. customThe reaction mixture was then evaporated to dryness under reduced pressure
  3. customisolated by filtration
  4. washwashing with ethyl acetate (2 mL)
  5. customThe solid was air-dried under suction
  6. customdried further under vacuo at 50° C

Quellen und Nachweise

ORD-Eintrag
ord-70d691defeeb4f9895a0a8af6cace0e2
Quelldatensatz
uspto-grants-2011_07
Patentnummer
US07977344B2

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