[CH3:1][C@@H:2]([O:6][C:7]1[N:15]=[C:14]2[C:10]([N:11]=[C:12]([O:22][CH3:23])[N:13]2C2CCCCO2)=[C:9]([NH2:24])[N:8]=1)[CH2:3][CH2:4][CH3:5].[F:25][C:26]([F:31])([F:30])[C:27]([OH:29])=[O:28]>CO.C(OCC)(=O)C>[F:25][C:26]([F:31])([F:30])[C:27]([OH:29])=[O:28].[CH3:1][C@@H:2]([O:6][C:7]1[NH:8][C:9]([NH2:24])=[C:10]2[C:14]([N:15]=1)=[N:13][C:12]([O:22][CH3:23])=[N:11]2)[CH2:3][CH2:4][CH3:5]To a solution of 2-{[(1R)-1-methylbutyl]oxy}-8-(methyloxy)-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-amine (4.8 g, 14.31 mmol) in methanol (100 ml) was added trifluoroacetic acid (8 ml, 104 mmol). The reaction mixture was stirred at room temperature for 72 hours. The solvent was removed in vacuo to give a pale yellow solid which was suspended in ethyl acetate (30 ml). The precipitate was filtered off and washed with further ethyl acetate until the filtrate was colourless. The remaining solid was dried by air and then in vacuo to give the title compound as a cream solid (3.85 g).
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