Isoamylamine → 6-amino-2-[(3-methylbutyl)amino]-9-(tetrahydro-2H-pyran-4-ylmethyl)-7,9-dihydro-8H-purin-8-one
Reaktionsgleichung
Cl[C:2]1[N:10]=[C:9]2[C:5]([N:6]=[C:7]([O:18]C)[N:8]2[CH2:11][CH:12]2[CH2:17][CH2:16][O:15][CH2:14][CH2:13]2)=[C:4]([NH2:20])[N:3]=1.[CH3:21][CH:22]([CH3:26])[CH2:23][CH2:24][NH2:25]>>[NH2:20][C:4]1[N:3]=[C:2]([NH:25][CH2:24][CH2:23][CH:22]([CH3:26])[CH3:21])[N:10]=[C:9]2[C:5]=1[NH:6][C:7](=[O:18])[N:8]2[CH2:11][CH:12]1[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1Komponenten
3
Reaktionsbedingungen
- Temperatur
- 170 °C
Versuchsvorschrift
A mixture of 2-chloro-8-methoxy-9-(tetrahydro-2H-pyran-4-ylmethyl)-9H-purin-6-amine (45 mg) in 3-methyl-1-butylamine (0.234 mL) was heated in a microwave at 170° C. for 10 mins. The mixture was concentrated in vacuo to give a green oily residue. This was purified by C18 reverse phase chromatography (ISCO) using water (0.1% formic acid)-acetonitrile (0.05% formic acid) as eluent (20-60%) to give the title compound as a white solid (10 mg).