m-Chloroperbenzoic acid → HCID 67314368, Verbindung

HRID 1011337Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1011337
[CH3:1][C:2]1[N:7]=[C:6]2[CH2:8][O:9][C:10](=[O:11])[C:5]2=[CH:4][CH:3]=1.ClC1C=C(C=CC=1)C(OO)=[O:17]>C(Cl)(Cl)Cl.ClCCl>[CH3:1][C:2]1[N+:7]([O-:17])=[C:6]2[CH2:8][O:9][C:10](=[O:11])[C:5]2=[CH:4][CH:3]=1

Komponenten

5

Edukt 2

HCID 70297m-Chloroperbenzoic acidHCID 58478770HCID 58478770, Verbindung

Produkt 1

HCID 67314368HCID 67314368, VerbindungAusbeute 73,9 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 6212ChloroformLösungsmittelHCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

A solution of 2-methyl-7H-furo[3,4-b]pyridin-5-one (150 mg, 1.0 mmol) in chloroform (5 mL) and dichloromethane (1 mL) is treated with m-chloroperoxybenzoic acid (258 mg, 1.5 mmol). The reaction mixture is stirred at room temperature overnight. The reaction mixture is concentrated and the residue is purified by chromatography (silica gel). The product containing fractions are concentrated to give the title compound as a solid (122 mg, 73%).

Aufarbeitung

  1. concentrationThe reaction mixture is concentrated
  2. customthe residue is purified by chromatography (silica gel)
  3. additionThe product containing fractions
  4. concentrationare concentrated

Quellen und Nachweise

ORD-Eintrag
ord-c4347257a2da4b3aa6bc7822e3403615
Quelldatensatz
uspto-grants-2011_07
Patentnummer
US07977351B2

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