Boron tribromide → 7-Hydroxy-3-(4,5-dihydro-4,4-dimethyl-2-oxazolyl)quinoline

HRID 1011428Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1011428
C[O:2][C:3]1[CH:12]=[C:11]2[C:6]([CH:7]=[C:8]([C:13]3[O:14][CH2:15][C:16]([CH3:19])([CH3:18])[N:17]=3)[CH:9]=[N:10]2)=[CH:5][CH:4]=1.B(Br)(Br)Br>ClCCl>[OH:2][C:3]1[CH:12]=[C:11]2[C:6]([CH:7]=[C:8]([C:13]3[O:14][CH2:15][C:16]([CH3:19])([CH3:18])[N:17]=3)[CH:9]=[N:10]2)=[CH:5][CH:4]=1

Komponenten

4

Edukt 2

HCID 25134Boron tribromideHCID 231597597-Methoxy-3-(4,5-dihydro-4,4-dimethyl-2-oxazolyl)quinoline

Produkt 1

HCID 1356182107-Hydroxy-3-(4,5-dihydro-4,4-dimethyl-2-oxazolyl)quinoline

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

A solution of 7-methoxy-3-(4,5-dihydro-4,4-dimethyl-2-oxazolyl)quinoline (2.56 g, 10 mmol) prepared in stage A and BBr3 (7.41 g, 30 mmol) in dichloromethane (40 mL) are stirred for 12 hours at room temperature. The mixture was quenched with saturated sodium hydrogen carbonate. Extraction with dichloromethane, drying (MgSO4) and evaporation furnished the desired compound.

Aufarbeitung

  1. customThe mixture was quenched with saturated sodium hydrogen carbonate
  2. extractionExtraction with dichloromethane
  3. customdrying
  4. custom(MgSO4) and evaporation

Quellen und Nachweise

ORD-Eintrag
ord-f08bfad8e287479db8bc5f23ab85c845
Quelldatensatz
uspto-grants-2011_07
Patentnummer
US07977354B2

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