Dimethyl Disulfide → HCID 23159742, Verbindung

HRID 1011434Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1011434
Br[C:2]1[CH:3]=[N:4][C:5]2[C:10]([CH:11]=1)=[C:9]([O:12][CH3:13])[CH:8]=[CH:7][CH:6]=2.[CH3:14][S:15]SC>C1COCC1>[CH3:13][O:12][C:9]1[CH:8]=[CH:7][CH:6]=[C:5]2[C:10]=1[CH:11]=[C:2]([S:15][CH3:14])[CH:3]=[N:4]2

Komponenten

4

Edukt 2

HCID 12232Dimethyl DisulfideHCID 231597643-Bromo-5-methoxyquinoline

Produkt 1

HCID 23159742HCID 23159742, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Reaktionsbedingungen

Temperatur
-78 °C

Versuchsvorschrift

To a solution of 3-bromo-5-methoxy quinoline (2.37 g, 10 mmol) prepared in stage B of example 10 in THF (25 mL) was added 2.5M n-buLi (4 mL, 10 mmol) at −78° C. The solution is stirred at −78° C. for 45 min and dimethyl disulfide (1.8 g, 20 mmol) is added. The resultant solution is stirred for 3 hours and then quenched with saturated NH4Cl (30 mL). Extraction with dichloromethane, drying, filtering and evaporation in vacuo afford the title compound

Aufarbeitung

  1. customquenched with saturated NH4Cl (30 mL)
  2. extractionExtraction with dichloromethane
  3. customdrying
  4. filtrationfiltering
  5. customevaporation in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-602bdd1194b34418b09bb0bb9e75ce08
Quelldatensatz
uspto-grants-2011_07
Patentnummer
US07977354B2

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