(2-Cyclohexylvinyl)boronic acid → {1-[3-((E)-2-Cyclohexyl-vinyl)-phenyl]-3,5-dimethyl-1H-pyrazol-4-yl]-(3-diethylamino-pyrrolidin-1-yl)-methanone
Reaktionsgleichung
Br[C:2]1[CH:3]=[C:4]([N:8]2[C:12]([CH3:13])=[C:11]([C:14]([N:16]3[CH2:20][CH2:19][CH:18]([N:21]([CH2:24][CH3:25])[CH2:22][CH3:23])[CH2:17]3)=[O:15])[C:10]([CH3:26])=[N:9]2)[CH:5]=[CH:6][CH:7]=1.[CH:27]1(/[CH:33]=[CH:34]/B(O)O)[CH2:32][CH2:31][CH2:30][CH2:29][CH2:28]1>>[CH:27]1(/[CH:33]=[CH:34]/[C:2]2[CH:3]=[C:4]([N:8]3[C:12]([CH3:13])=[C:11]([C:14]([N:16]4[CH2:20][CH2:19][CH:18]([N:21]([CH2:24][CH3:25])[CH2:22][CH3:23])[CH2:17]4)=[O:15])[C:10]([CH3:26])=[N:9]3)[CH:5]=[CH:6][CH:7]=2)[CH2:32][CH2:31][CH2:30][CH2:29][CH2:28]1Komponenten
3
Edukt 2
Produkt 1
Versuchsvorschrift
In analogy to the procedure described in Example 14C], [1-(3-bromo-phenyl)-3,5-dimethyl-1H-pyrazol-4-yl]-(3-diethylamino-pyrrolidin-1-yl)-methanone (Example 30A]) and trans-2-cyclohexylvinylboronic acid gave the title compound in 40% yield as brown gum. MS: 449.3 (MH+).