(3-Diethylamino-pyrrolidin-1-yl)-[3,5-dimethyl-1-[3-(3-methyl-but-1-ynyl)-phenyl]-1H-pyrazol-4-yl}-methanone → (3-Diethylamino-pyrrolidin-1-yl)-[3,5-dimethyl-1-[3-(3-methyl-butyl)-phenyl]-1H-pyrazol-4-yl}-methanone

HRID 1011930

Reaktionsgleichung

Reaktionsgleichung von HRID 1011930
[CH2:1]([N:3]([CH2:29][CH3:30])[CH:4]1[CH2:8][CH2:7][N:6]([C:9]([C:11]2[C:12]([CH3:28])=[N:13][N:14]([C:17]3[CH:22]=[CH:21][CH:20]=[C:19]([C:23]#[C:24][CH:25]([CH3:27])[CH3:26])[CH:18]=3)[C:15]=2[CH3:16])=[O:10])[CH2:5]1)[CH3:2]>CCO.O.[Pt](=O)=O>[CH2:29]([N:3]([CH2:1][CH3:2])[CH:4]1[CH2:8][CH2:7][N:6]([C:9]([C:11]2[C:12]([CH3:28])=[N:13][N:14]([C:17]3[CH:22]=[CH:21][CH:20]=[C:19]([CH2:23][CH2:24][CH:25]([CH3:26])[CH3:27])[CH:18]=3)[C:15]=2[CH3:16])=[O:10])[CH2:5]1)[CH3:30]

Komponenten

4

Edukt 1

HCID 57554954(3-Diethylamino-pyrrolidin-1-yl)-[3,5-dimethyl-1-[3-(3-methyl-but-1-ynyl)-phenyl]-1H-pyrazol-4-yl}-methanone

Produkt 1

HCID 57555039(3-Diethylamino-pyrrolidin-1-yl)-[3,5-dimethyl-1-[3-(3-methyl-butyl)-phenyl]-1H-pyrazol-4-yl}-methanoneAusbeute 93 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 11139377Platinum dioxide monohydrateKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

A suspension of 0.041 g (0.10 mmol) of (3-diethylamino-pyrrolidin-1-yl)-{3,5-dimethyl-1-[3-(3-methyl-but-1-ynyl)-phenyl]-1H-pyrazol-4-yl}-methanone (Example 361) and 6 mg of platinum(IV) oxide hydrate in 0.2 ml of EtOH was stirred under hydrogen atmosphere 17 h at RT and 1 atm. The suspension was filtered and evaporated to give 0.038 g (93%) of the titled compound as colorless viscous oil. MS: 411.2 (MH+).

Aufarbeitung

  1. filtrationThe suspension was filtered
  2. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-6b66d41878584d2485f559ec90ee3ee0
Quelldatensatz
uspto-grants-2011_07
Patentnummer
US07977358B2

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