HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Sodium hydride → 1-(2-Chloropyrimidin-5-ylsulfonyl)-5-phenyl-1H-pyrrole-3-carbaldehyde
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Sodium hydride | HCID 24758 | — |
| Edukt | 15-Crown-5 | HCID 36336 | — |
| Edukt | 5-Phenyl-1H-pyrrole-3-carboxaldehyde | HCID 11052090 | — |
| Edukt | 2-Chloropyrimidine-5-sulfonyl chloride | HCID 43244366 | — |
| Produkt | 1-(2-Chloropyrimidin-5-ylsulfonyl)-5-phenyl-1H-pyrrole-3-carbaldehyde | HCID 86620758 | — |
Reaktionsschritte
By a reaction under similar conditions as in Reference Example 55 and using 5-phenyl-1H-pyrrole-3-carbaldehyde (342 mg), sodium hydride (60% in oil, 120 mg), 15-crown-5 (0.60 mL) and 2-chloro-5-pyrimidinesulfonyl chloride (554 mg), the title compound was obtained as a yellow solid (yield 390 mg, 56%).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07977488B2 |
| Quelldatensatz | uspto-grants-2011_07 |
| ORD ID | ord-79adac6642024d4ca4afa128dc523e20 |
| Quellennotiz | uspto-grants-2011_07 |