O-[(2-Methyl-4-thiazolyl)methyl]hydroxylamine → HCID 11261047, Verbindung

HRID 1012667Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1012667
[Cl:1][C:2]1[CH:19]=[C:18]([NH:20][C:21]2[CH:26]=[CH:25][C:24]([F:27])=[CH:23][C:22]=2[F:28])[CH:17]=[CH:16][C:3]=1[C:4]([C:6]1[CH:7]=[C:8]([CH:12]=[CH:13][C:14]=1[CH3:15])[C:9](O)=[O:10])=[O:5].[CH3:29][C:30]1[S:31][CH:32]=[C:33]([CH2:35][O:36][NH2:37])[N:34]=1>>[Cl:1][C:2]1[CH:19]=[C:18]([NH:20][C:21]2[CH:26]=[CH:25][C:24]([F:27])=[CH:23][C:22]=2[F:28])[CH:17]=[CH:16][C:3]=1[C:4]([C:6]1[CH:7]=[C:8]([CH:12]=[CH:13][C:14]=1[CH3:15])[C:9]([NH:37][O:36][CH2:35][C:33]1[N:34]=[C:30]([CH3:29])[S:31][CH:32]=1)=[O:10])=[O:5]

Komponenten

3

Edukt 2

HCID 425143O-[(2-Methyl-4-thiazolyl)methyl]hydroxylamineHCID 586776023-[2-Chloro-4-(2,4-difluorophenylamino)benzoyl]-4-methylbenzoic acid

Produkt 1

HCID 11261047HCID 11261047, Verbindung

Versuchsvorschrift

Compound 424 (50 mg, 0.12 mmol) and O-(2-Methyl-thiazol-4-ylmethyl)-hydroxylamine (36 mg, 0.25 mmol) were treated as described for compound 337. Flash chromatography (ethyl acetate/petroleum ether: graduated from 67/33 to 100/0) provided the title compound. 1H NMR (CDCl3) δ 10.0-9.0 (bs, 1H), 7.76 (dd, 1H), 7.67 (d, 1H), 7.42-7.30 (m, 3H), 7.15 (s, 1H), 7.00-6.84 (m, 3H), 6.75 (dd, 1H), 5.98 (bs, 1H), 5.04 (s, 2H), 2.64 (s, 3H), 2.45 (s, 3H)

Quellen und Nachweise

ORD-Eintrag
ord-fcd0a38861454805b85a9b91e420a008
Quelldatensatz
uspto-grants-2011_07
Patentnummer
US07977387B2

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