O-((4-Methoxyphenyl)methyl)hydroxylamine → HCID 58677577, Verbindung

HRID 1012669Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1012669
[Cl:1][C:2]1[CH:19]=[C:18]([NH:20][C:21]2[CH:26]=[CH:25][C:24]([F:27])=[CH:23][C:22]=2[F:28])[CH:17]=[CH:16][C:3]=1[C:4]([C:6]1[CH:7]=[C:8]([CH:12]=[CH:13][C:14]=1[CH3:15])[C:9](O)=[O:10])=[O:5].[CH3:29][O:30][C:31]1[CH:39]=[CH:38][C:34]([CH2:35][O:36][NH2:37])=[CH:33][CH:32]=1>>[Cl:1][C:2]1[CH:19]=[C:18]([NH:20][C:21]2[CH:26]=[CH:25][C:24]([F:27])=[CH:23][C:22]=2[F:28])[CH:17]=[CH:16][C:3]=1[C:4]([C:6]1[CH:7]=[C:8]([CH:12]=[CH:13][C:14]=1[CH3:15])[C:9]([NH:37][O:36][CH2:35][C:34]1[CH:38]=[CH:39][C:31]([O:30][CH3:29])=[CH:32][CH:33]=1)=[O:10])=[O:5]

Komponenten

3

Edukt 2

HCID 120426O-((4-Methoxyphenyl)methyl)hydroxylamineHCID 586776023-[2-Chloro-4-(2,4-difluorophenylamino)benzoyl]-4-methylbenzoic acid

Produkt 1

HCID 58677577HCID 58677577, Verbindung

Versuchsvorschrift

Compound 424 (100 mg, 0.25 mmol) and O-(4-methoxy-benzyl)-hydroxylamine (65 mg, 0.34 mmol) were treated as described for compound 337. Flash chromatography (ethyl acetate/petroleum ether: graduated from 80/20 to 60/40) provided the title compound. 13C NMR (CDCl3) δ 195.3, 165.6, 160.1, 159.3 (dd), 155.7 (dd), 148.2, 142.1, 139.7, 135.3, 133.8, 131.7, 131.1, 129.4, 129.1, 128.6, 127.8, 127.2, 124.6 (dd), 124.2 (dd), 116.2, 114.1, 112.8, 111.6 (dd), 105.0 (dd), 78.0, 55.3, 20.4

Quellen und Nachweise

ORD-Eintrag
ord-9d1e77b71cd94ab7a0ce6ae74f8781a9
Quelldatensatz
uspto-grants-2011_07
Patentnummer
US07977387B2

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