1,1-Dimethylhydrazine → HCID 11259322, Verbindung

HRID 1012670Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1012670
[Cl:1][C:2]1[CH:19]=[C:18]([NH:20][C:21]2[CH:26]=[CH:25][C:24]([F:27])=[CH:23][C:22]=2[F:28])[CH:17]=[CH:16][C:3]=1[C:4]([C:6]1[CH:7]=[C:8]([CH:12]=[CH:13][C:14]=1[CH3:15])[C:9](O)=[O:10])=[O:5].[CH3:29][N:30]([CH3:32])[NH2:31]>>[CH3:29][N:30]([CH3:32])[NH:31][C:9](=[O:10])[C:8]1[CH:12]=[CH:13][C:14]([CH3:15])=[C:6]([C:4](=[O:5])[C:3]2[CH:16]=[CH:17][C:18]([NH:20][C:21]3[CH:26]=[CH:25][C:24]([F:27])=[CH:23][C:22]=3[F:28])=[CH:19][C:2]=2[Cl:1])[CH:7]=1

Komponenten

3

Edukt 2

HCID 59761,1-DimethylhydrazineHCID 586776023-[2-Chloro-4-(2,4-difluorophenylamino)benzoyl]-4-methylbenzoic acid

Produkt 1

HCID 11259322HCID 11259322, Verbindung

Versuchsvorschrift

Compound 424 (50 mg, 0.12 mmol) and N,N-dimethyl-hydrazine (19 μL, 0.25 mmol) were treated as described for compound 337. Flash chromatography (ethyl acetate/petroleum ether: graduated from 67/33 to 80/20) provided the title compound. 13C NMR (DMSO-d6) δ 194.7, 163.2, 158.9 (dd), 155.9 (dd), 149.6, 139.6, 139.5, 133.9, 133.8, 131.3, 131.0, 129.1, 127.2, 126.7 (dd), 126.3, 124.2 (dd), 114.9, 112.0 (dd), 111.9, 105.1 (dd), 46.1, 19.6

Quellen und Nachweise

ORD-Eintrag
ord-5118198a5b184289b10c2ccca0a7617b
Quelldatensatz
uspto-grants-2011_07
Patentnummer
US07977387B2

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