(2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanal → (3R,5S)-6-benzoyloxy-3,5-dihydroxyhexanoic tert-butyl ester

HRID 10131

Reaktionsgleichung

Reaktionsgleichung von HRID 10131
[C:1]([O:5][C:6](=[O:23])[CH2:7][C:8](=[O:22])[CH2:9][C@H:10]([OH:21])[CH2:11][O:12][C:13](=[O:20])[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)([CH3:4])([CH3:3])[CH3:2].O=C[C@@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O>P([O-])([O-])([O-])=O>[C:1]([O:5][C:6](=[O:23])[CH2:7][C@H:8]([OH:22])[CH2:9][C@H:10]([OH:21])[CH2:11][O:12][C:13](=[O:20])[C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=1)([CH3:4])([CH3:2])[CH3:3]

Komponenten

4

Edukt 2

HCID 107526(2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanalHCID 15099849(S)-6-benzoyloxy-3-oxo-5-hydroxyhexanoic acid tert-butylester

Produkt 1

HCID 11484150(3R,5S)-6-benzoyloxy-3,5-dihydroxyhexanoic tert-butyl ester

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1061PhosphateLösungsmittel

Versuchsvorschrift

Using 5 ml of Medium C described hereinbefore, the microorganisms indicated in Table 4 were cultured in the same manner as in Example 11. From 5 ml of each culture, the cells were centrifugally harvested, suspended in 0.5 ml of 100 mM phosphate buffer (pH 6.5) containing 0.05% of (5S)-6-benzoyloxy-5-hydroxy-3-oxohexanoic tert-butyl ester and 8% of glucose, and the reaction was carried out in the same manner. The results are shown in Table 4.

Quellen und Nachweise

ORD-Eintrag
ord-bf0fdec98e874af7be6a18c9a6110a97
Quelldatensatz
uspto-grants-2006_08
Patentnummer
US07094594B2

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