HCID 67206463, Verbindung → HCID 67206550, Verbindung

HRID 1013409Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1013409
C([O:3][C:4]([CH:6]1[CH:10]([C:11]2[CH:15]=[CH:14][S:13][CH:12]=2)[CH2:9][N:8]([CH:16]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[CH3:17])[CH2:7]1)=[O:5])C.C1NCC2C1CC1C(C#N)=CSC=12>Cl>[C:18]1([CH:16]([N:8]2[CH2:9][CH:10]([C:11]3[CH:15]=[CH:14][S:13][CH:12]=3)[CH:6]([C:4]([OH:5])=[O:3])[CH2:7]2)[CH3:17])[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1

Komponenten

4

Edukt 2

HCID 67206463HCID 67206463, VerbindungHCID 683017591,2,3,3a,7,7a-Hexahydro-4-thia-2-aza-cyclopenta[alpha]pentalene-6-carbonitrile

Produkt 1

HCID 67206550HCID 67206550, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 313Hydrochloric AcidLösungsmittel

Reaktionsbedingungen

Temperatur
80 °C

Versuchsvorschrift

The product from step b), diastereomer 1 (1.4 g, 4.3 mmol) was dissolved in 12 M HCl (10 mL) and was stirred at 80° C. for 12 hours. The reaction mix then was cooled to room temperature and evaporated to dryness to afford the subtitle compound. MS calculated for C17H19NO2S +H: 302, observed: 302.

Aufarbeitung

  1. additionThe reaction mix
  2. temperaturethen was cooled to room temperature
  3. customevaporated to dryness

Quellen und Nachweise

ORD-Eintrag
ord-14f1d9d3cc00421a9760ff6b14814118
Quelldatensatz
uspto-grants-2011_07
Patentnummer
US07981919B2

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