HCID 67205102, Verbindung → 1-(1-Phenyl-ethyl)-4-thiophen-2-yl-pyrrolidine-3-carboxylic acid

HRID 1013415Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1013415
C([O:3][C:4]([CH:6]1[CH:10]([C:11]2[S:12][CH:13]=[CH:14][CH:15]=2)[CH2:9][N:8]([CH:16]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[CH3:17])[CH2:7]1)=[O:5])C.C1NCC2C1CC1C(C#N)=CSC=12>>[C:18]1([CH:16]([N:8]2[CH2:9][CH:10]([C:11]3[S:12][CH:13]=[CH:14][CH:15]=3)[CH:6]([C:4]([OH:5])=[O:3])[CH2:7]2)[CH3:17])[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1

Komponenten

3

Edukt 2

HCID 67205102HCID 67205102, VerbindungHCID 683017591,2,3,3a,7,7a-Hexahydro-4-thia-2-aza-cyclopenta[alpha]pentalene-6-carbonitrile

Produkt 1

HCID 672065311-(1-Phenyl-ethyl)-4-thiophen-2-yl-pyrrolidine-3-carboxylic acid

Versuchsvorschrift

The product from step b), diastereomer 1 (5.8 g, 0.019 mol) was treated by the method outlined in Example 34, step c) to afford the subtitle compound that was used in the next step without further purification. MS calculated for C17H19NO2S +H: 302, observed: 302.

Quellen und Nachweise

ORD-Eintrag
ord-582bd42a8276480dab9616b25110e0c3
Quelldatensatz
uspto-grants-2011_07
Patentnummer
US07981919B2

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