Phosphorus oxide (P4O10) → 1-Methyl-5-trifluoromethyl-3,4-dihydro-isoquinoline

Reaktionsgleichung

[F:1][C:2]([F:16])([F:15])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[CH2:9][CH2:10][NH:11][C:12](=O)[CH3:13].O=P12OP3(OP(OP(O3)(O1)=O)(=O)O2)=O>>[CH3:13][C:12]1[C:5]2[C:4](=[C:3]([C:2]([F:16])([F:15])[F:1])[CH:8]=[CH:7][CH:6]=2)[CH2:9][CH2:10][N:11]=1

Komponenten

Edukt 2

HCID 14812Phosphorus oxide (P4O10)

HCID 58416419N-[2-(2-Trifluoromethyl-phenyl)-ethyl]-acetamide

Produkt 1

HCID 584164091-Methyl-5-trifluoromethyl-3,4-dihydro-isoquinoline

Versuchsvorschrift

In close analogy to the procedure described above, N-[2-(2-trifluormethyl-phenyl)-ethyl]-acetamide is reacted with phosphorus pentoxide to provide the title compound.

Quellen und Nachweise

ORD-Eintrag: ord-910acacf4562415a826a0a684ee4f614
Quelldatensatz: uspto-grants-2011_07
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US07985753B2

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