Boronic Acid → 1-Methyl-6-pyridin-3-yl-1,2,3,4-tetrahydro-isoquinoline

HRID 1015077Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1015077
Br[C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH:8]([CH3:12])[NH:7][CH2:6][CH2:5]2.B(O)O>>[CH3:12][CH:8]1[C:9]2[C:4](=[CH:3][C:2]([C:5]3[CH:6]=[N:7][CH:8]=[CH:9][CH:4]=3)=[CH:11][CH:10]=2)[CH2:5][CH2:6][NH:7]1

Komponenten

3

Edukt 2

HCID 61668Boronic AcidHCID 596625906-Bromo-1-methyl-1,2,3,4-tetrahydroisoquinoline

Produkt 1

HCID 584164041-Methyl-6-pyridin-3-yl-1,2,3,4-tetrahydro-isoquinoline

Versuchsvorschrift

In close analogy to the procedure described above, 6-Bromo-1-methyl-1,2,3,4-tetrahydro-isoquinoline is reacted with the corresponding boronic acid to provide the title compound.

Quellen und Nachweise

ORD-Eintrag
ord-f475a4adb4174538aeaf85003349c348
Quelldatensatz
uspto-grants-2011_07
Patentnummer
US07985753B2

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