6-Chloropyrazolo[1,5-A]pyrimidine-2-carboxylic acid → HCID 58416366, Verbindung
Reaktionsgleichung
[Cl:1][C:2]1[CH:3]=[N:4][C:5]2[N:6]([N:8]=[C:9]([C:11]([OH:13])=O)[CH:10]=2)[CH:7]=1.[CH3:14][CH:15]1[C:24]2[C:19](=[C:20]([NH:25][C:26](=[O:28])[CH3:27])[CH:21]=[CH:22][CH:23]=2)[CH2:18][CH2:17][NH:16]1>>[Cl:1][C:2]1[CH:3]=[N:4][C:5]2[N:6]([N:8]=[C:9]([C:11]([N:16]3[CH2:17][CH2:18][C:19]4[C:24](=[CH:23][CH:22]=[CH:21][C:20]=4[NH:25][C:26](=[O:28])[CH3:27])[CH:15]3[CH3:14])=[O:13])[CH:10]=2)[CH:7]=1Komponenten
3
Versuchsvorschrift
In close analogy to the procedure described in Example 1, 6-chloro-pyrazolo[1,5-a]pyrimidine-2-carboxylic acid is reacted with N-(1-Methyl-1,2,3,4-tetrahydro-isoquinolin-5-yl)-acetamide to provide the title compound in moderate yield.
Quellen und Nachweise
- ORD-Eintrag
- ord-d85748b7085049e8b3a48f6e845d8868
- Quelldatensatz
- uspto-grants-2011_07
- Patentnummer
- US07985753B2