Hydrochloric Acid → 2-(Ethylsulfanyl)-5-methylbenzonitrile

HRID 1015743

Reaktionsgleichung

Reaktionsgleichung von HRID 1015743
F[C:2]1[CH:9]=[CH:8][C:7]([CH3:10])=[CH:6][C:3]=1[C:4]#[N:5].[CH2:11]([S-:13])[CH3:12].[Na+].Cl>CN(C)C=O>[CH2:11]([S:13][C:2]1[CH:9]=[CH:8][C:7]([CH3:10])=[CH:6][C:3]=1[C:4]#[N:5])[CH3:12]

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 27745842-Fluoro-5-methylbenzonitrileHCID 4459711Sodium ethanethiolate

Produkt 1

HCID 668771452-(Ethylsulfanyl)-5-methylbenzonitrileAusbeute 87,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

(Step 1) A mixture of 2-fluoro-5-methylbenzonitrile (7.5 g) and sodium ethanethiolate (4.9 g) was stirred in N,N-dimethylformamide (30 ml) at room temperature for 3 hr. The reaction solution was treated with 1N hydrochloric acid, and extracted with ethyl acetate. The extract was washed with saturated brine, and dried over magnesium sulfate. The solvent was evaporated under reduced pressure to give 2-(ethylsulfanyl)-5-methylbenzonitrile (8.57 g).

Aufarbeitung

  1. extractionextracted with ethyl acetate
  2. washThe extract was washed with saturated brine
  3. dry with materialdried over magnesium sulfate
  4. customThe solvent was evaporated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-3540f1aafcae4e879552d8a076d04358
Quelldatensatz
uspto-grants-2011_07
Patentnummer
US07985862B2

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