[1,2,4]Triazolo[1,5-a]pyrazine-2-carboxylic acid, ethyl ester, 3-oxide → HCID 67485099, Verbindung

HRID 1016419Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1016419
[N:1]1[C:2]([C:11]([O:13][CH2:14][CH3:15])=[O:12])=[N+:3]([O-])[N:4]2[CH:9]=[CH:8][N:7]=[CH:6][C:5]=12>P(OCC)(OCC)OCC>[CH2:14]([O:13][C:11]([C:2]1[N:1]=[C:5]2[CH:6]=[N:7][CH:8]=[CH:9][N:4]2[N:3]=1)=[O:12])[CH3:15]

Komponenten

3

Edukt 1

HCID 12308357[1,2,4]Triazolo[1,5-a]pyrazine-2-carboxylic acid, ethyl ester, 3-oxide

Produkt 1

HCID 67485099HCID 67485099, VerbindungAusbeute 22,8 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 31215Triethyl phosphiteLösungsmittel

Versuchsvorschrift

Ethyl 1,2,4-triazolo[1,5-a]pyrazine-2-carboxylate-3-oxide (prepared as described in J. Chem. Soc., Perkin Trans. 1, 1976, 2166) (2.0 g, 9.6 mmol) was stirred in triethyl phosphite (20 ml) at 100° C. for 1 h. The solvent was concentrated in vacuo, and the crude product was triturated with diethyl ether (50 ml). The precipitated solid was separated by filtration, and purified by flash chromatography on silica gel, eluting with 1:1 dichloromethane:ethyl acetate, yielding [1,2,4]triazolo[1,5-a]pyrazine-2-carboxylic acid ethyl ester as a pale orange solid (420 mg). Data for the title compound: 1H NMR (360 MHz, CDCl3) δ 1.51 (3H, t, J=7.1 Hz), 4.59 (2H, q, J=7.1 Hz), 8.34 (1H, d, J=4.5 Hz), 8.63 (1H, d, J=4.5 Hz), 9.43 (1H, s); MS (ES+) m/e 193 [MH]+.

Aufarbeitung

  1. concentrationThe solvent was concentrated in vacuo
  2. customthe crude product was triturated with diethyl ether (50 ml)
  3. customThe precipitated solid was separated by filtration
  4. custompurified by flash chromatography on silica gel
  5. washeluting with 1:1 dichloromethane

Quellen und Nachweise

ORD-Eintrag
ord-1b5af580deac4fb89792f6665a17468b
Quelldatensatz
uspto-grants-2002_11
Patentnummer
US06476030B1

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