Hydrochloric Acid → 3-[2-(Dibutylamino)ethylamino]-1-nonyl-pyrrolidine-2,5-dione

HRID 1016524

Reaktionsgleichung

Reaktionsgleichung von HRID 1016524
[CH2:1]([N:10]1[C:14](=[O:15])[CH:13]=[CH:12][C:11]1=[O:16])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH3:9].C(N(CC)CC)C.[CH2:24]([N:28]([CH2:32][CH2:33][CH2:34][CH3:35])[CH2:29][CH2:30][NH2:31])[CH2:25][CH2:26][CH3:27].Cl>C(#N)C.C(OCC)(=O)C>[CH2:24]([N:28]([CH2:32][CH2:33][CH2:34][CH3:35])[CH2:29][CH2:30][NH:31][CH:13]1[CH2:12][C:11](=[O:16])[N:10]([CH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH3:9])[C:14]1=[O:15])[CH2:25][CH2:26][CH3:27]

Komponenten

7

Edukt 4

HCID 313Hydrochloric AcidHCID 8471TriethylamineHCID 77062N,N-DibutylethylenediamineHCID 512831N-Nonylmaleimide

Produkt 1

HCID 5128573-[2-(Dibutylamino)ethylamino]-1-nonyl-pyrrolidine-2,5-dione

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 6342AcetonitrileLösungsmittelHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

N-nonyl maleimide (0.02 mM) prepared as described in Example 12 above in 2 ml of acetonitrile was treated with one equivalent of triethylamine and one equivalent of N,N-dibutylethylenediamine. The reaction mixture was stirred for six hours and then the acetonitrile was evaporated. The residue obtained was treated with cold aqueous dilute hydrochloric acid solution and ethyl acetate, with stirring for one hour. The ethyl acetate layer was then separated and concentrated to give the desired product.

Aufarbeitung

  1. customthe acetonitrile was evaporated
  2. customThe residue obtained
  3. stirringwith stirring for one hour
  4. customThe ethyl acetate layer was then separated
  5. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-d2a58ec7360943a4acba299008de7e77
Quelldatensatz
uspto-grants-2002_11
Patentnummer
US06476053B1

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