Acetone → Methyl 3-methoxy-4-iodo-2-naphthoate

HRID 1016623Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1016623
[OH:1][C:2]1[C:3]([C:13]([OH:15])=O)=[CH:4][C:5]2[C:10]([C:11]=1[I:12])=[CH:9][CH:8]=[CH:7][CH:6]=2.S([O:21][CH3:22])(OC)(=O)=O.[C:23](=O)([O-])[O-].[K+].[K+].CC(C)=O>C(N(CC)CC)C>[CH3:23][O:1][C:2]1[C:3]([C:13]([O:21][CH3:22])=[O:15])=[CH:4][C:5]2[C:10]([C:11]=1[I:12])=[CH:9][CH:8]=[CH:7][CH:6]=2

Komponenten

6

Edukt 4

HCID 180AcetoneHCID 6497Dimethyl SulfateHCID 11430Potassium CarbonateHCID 2422513-Hydroxy-4-iodonaphthalene-2-carboxylic acid

Produkt 1

HCID 11110626Methyl 3-methoxy-4-iodo-2-naphthoateAusbeute 63,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8471TriethylamineLösungsmittel

Versuchsvorschrift

A solution of 3-hydroxy-4-iodo-2-naphthoic acid (8.0 g), dimethyl sulfate (8.03 g), powdered potassium carbonate (8.80 g), and dry acetone (150 mL) was heated under reflux for 18 h. The solution was cooled to room temperature, triethylamine (15 mL) was added, and stirring continued for 30 min. The solution was filtered through a pad of Celite and washed with dry acetone (50 mL). The filtrate was concentrated to a yellow oil, diluted with EtOAc, and washed successively with 1N HCl (100 mL), saturated aqueous sodium bicarbonate (100 mL), and brine (100 mL). The organic phase was dried (sodium sulfate), filtered, concentrated, and purified by chromatography (0-10% EtOAc in hexanes) to afford the product as a yellow oil (5.53 g). 1H NMR (DMSO-d6) δ8.47 (s,1 H), 8.09 (m,2 H), 7.74 (m, 1 H), 7.61 (m, 1 H), 3.94 (s,3 H), 3.87 (s,3 H).

Aufarbeitung

  1. temperatureunder reflux for 18 h
  2. filtrationThe solution was filtered through a pad of Celite
  3. washwashed with dry acetone (50 mL)
  4. concentrationThe filtrate was concentrated to a yellow oil
  5. additiondiluted with EtOAc
  6. washwashed successively with 1N HCl (100 mL), saturated aqueous sodium bicarbonate (100 mL), and brine (100 mL)
  7. dry with materialThe organic phase was dried (sodium sulfate)
  8. filtrationfiltered
  9. concentrationconcentrated
  10. custompurified by chromatography (0-10% EtOAc in hexanes)

Quellen und Nachweise

ORD-Eintrag
ord-3ef2ea5df38049d4beb82d24dede14fd
Quelldatensatz
uspto-grants-2002_11
Patentnummer
US06476077B1

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