4-(Methanesulfonyl)-3-nitrobenzoic acid → 3-Amino-4-methylsulfonylbenzoic acid

HRID 1017125Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1017125
[N+:1]([C:4]1[CH:5]=[C:6]([CH:10]=[CH:11][C:12]=1[S:13]([CH3:16])(=[O:15])=[O:14])[C:7]([OH:9])=[O:8])([O-])=O.[H][H]>[Ni].CO>[NH2:1][C:4]1[CH:5]=[C:6]([CH:10]=[CH:11][C:12]=1[S:13]([CH3:16])(=[O:15])=[O:14])[C:7]([OH:9])=[O:8]

Komponenten

5

Edukt 2

HCID 27238714-(Methanesulfonyl)-3-nitrobenzoic acidHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 227288903-Amino-4-methylsulfonylbenzoic acid

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 935NickelKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

0.447 mol of 3-nitro-4-methylsulfonylbenzoic acid was reduced with hydrogen by employing 100 g of Raney nickel in 2.5 l of methanol. The mixture was then heated to reflux and filtered off hot with suction. The filtrate was concentrated.

Aufarbeitung

  1. temperatureThe mixture was then heated
  2. temperatureto reflux
  3. filtrationfiltered off hot with suction
  4. concentrationThe filtrate was concentrated

Quellen und Nachweise

ORD-Eintrag
ord-93a46b0ed8fb46ea8f5d878cb19bb8f1
Quelldatensatz
uspto-grants-2002_11
Patentnummer
US06479436B1

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