Nitric Acid → 6-Methyl-5-nitroquinoline

HRID 1017128

Reaktionsgleichung

Reaktionsgleichung von HRID 1017128
[CH3:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[CH:7][CH:6]=[CH:5]2.S(=O)(=O)(O)O.[N+:17]([O-])([OH:19])=[O:18].[OH-].[Na+]>>[N+:17]([C:3]1[C:2]([CH3:1])=[CH:11][CH:10]=[C:9]2[C:4]=1[CH:5]=[CH:6][CH:7]=[N:8]2)([O-:19])=[O:18]

Komponenten

5

Edukt 4

HCID 944Nitric AcidHCID 1118Sulfuric AcidHCID 70596-MethylquinolineHCID 14798Sodium Hydroxide

Produkt 1

HCID 900096-Methyl-5-nitroquinoline

Versuchsvorschrift

2.45 mol of 6-methylquinoline were added to 1 l of concentrated sulfuric acid, and 2.94 mol of 65% strength nitric acid were added dropwise at from 0 to 10° C. The mixture was stirred for one hour, poured onto ice, adjusted to pH 2.5 using aqueous sodium hydroxide solution, filtered off with suction, washed with water and dried over magnesium sulfate.

Aufarbeitung

  1. additionwere added dropwise at from 0 to 10° C
  2. additionpoured onto ice
  3. filtrationfiltered off with suction
  4. washwashed with water
  5. dry with materialdried over magnesium sulfate

Quellen und Nachweise

ORD-Eintrag
ord-fba0f63ffa8d41a3a1766704edbaa66d
Quelldatensatz
uspto-grants-2002_11
Patentnummer
US06479436B1

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