Methyl iodide → 5-methoxy-1-methyl-1H-indole
Reaktionsgleichung
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[NH:8][CH:7]=[CH:6]2.[OH-].[K+].[CH3:14]I>CN(C=O)C>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[N:8]([CH3:14])[CH:7]=[CH:6]2Komponenten
5
Edukt 3
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
To a solution of 5-methoxyindole (1 g, 6.8 mmol) in 8 mL of DMF were added potassium hydroxide (0.92 g, 2.4 eq.) and methyl iodide (1 mL, 16 mmol). The resulting mixture was stirred at room temperature overnight. After removing volatile, the residue was diluted with EtOAc and washed with water (4×). The organic layer was dried and concentrated to afford 0.9 g (82%) 5-methoxy-1-methylindole. MS (EI): (M++1) 162.
Aufarbeitung
- customAfter removing volatile
- additionthe residue was diluted with EtOAc
- washwashed with water (4×)
- customThe organic layer was dried
- concentrationconcentrated
Quellen und Nachweise
- ORD-Eintrag
- ord-a42b9acf5e5147af8e98fb0c35a46f67
- Quelldatensatz
- uspto-grants-2002_11
- Patentnummer
- US06479490B2
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