Sodium Hydroxide → 3-(3-Benzyl-3h-imidazol-4-yl)-1-(4-isobutylphenyl)-propen-1-one

HRID 1017743

Reaktionsgleichung

Reaktionsgleichung von HRID 1017743
[CH3:1][CH:2]([CH2:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]([CH3:13])=[O:12])=[CH:7][CH:6]=1)[CH3:3].[CH2:14]([N:21]1[C:25]([CH:26]=O)=[CH:24][N:23]=[CH:22]1)[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1.[OH-].[Na+]>CO>[CH2:14]([N:21]1[C:25]([CH:26]=[CH:13][C:11]([C:8]2[CH:7]=[CH:6][C:5]([CH2:4][CH:2]([CH3:1])[CH3:3])=[CH:10][CH:9]=2)=[O:12])=[CH:24][N:23]=[CH:22]1)[C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=1

Komponenten

5

Edukt 3

HCID 14798Sodium HydroxideHCID 932144'-IsobutylacetophenoneHCID 27732391-Benzyl-1H-imidazole-5-carboxaldehyde

Produkt 1

HCID 537079343-(3-Benzyl-3h-imidazol-4-yl)-1-(4-isobutylphenyl)-propen-1-one

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

A solution of 4-isobutylacetophenone (2.0 g), 3-benzyl-3H-imidazole-4-carbaldehyde (2.1 g) and 48% sodium hydroxide (0.65 ml) in methanol (20 ml) is heated at 55-60° C. for 6 hours. The reaction mixture is then cooled in an ice bath. The resulting precipitate is filtered, and rinsed with methanol. The yield is 2.5 g.

Aufarbeitung

  1. temperatureThe reaction mixture is then cooled in an ice bath
  2. filtrationThe resulting precipitate is filtered
  3. washrinsed with methanol

Quellen und Nachweise

ORD-Eintrag
ord-ac275b4941a24169bdd390a2461dec08
Quelldatensatz
uspto-grants-2002_11
Patentnummer
US06479530B2

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