Chloroform → (-)-5,6-Dimethoxy-2-[2,2,4,6,7-pentamethyl-3-(4-ethylphenyl)-2,3-dihydro-1-benzofuran-5-yl]isoindoline hydrochloride

HRID 1017850

Reaktionsgleichung

Reaktionsgleichung von HRID 1017850
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][C:11]=1[O:12][CH3:13])[CH2:8][N:7]([C:14]1[C:15]([CH3:34])=[C:16]([CH3:33])[C:17]3[O:21][C:20]([CH3:23])([CH3:22])[CH:19]([C:24]4[CH:29]=[CH:28][C:27]([CH3:30])=[CH:26][CH:25]=4)[C:18]=3[C:31]=1[CH3:32])[CH2:6]2.[CH:35](Cl)(Cl)[Cl:36]>>[ClH:36].[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][C:11]=1[O:12][CH3:13])[CH2:8][N:7]([C:14]1[C:15]([CH3:34])=[C:16]([CH3:33])[C:17]3[O:21][C:20]([CH3:23])([CH3:22])[CH:19]([C:24]4[CH:25]=[CH:26][C:27]([CH2:30][CH3:35])=[CH:28][CH:29]=4)[C:18]=3[C:31]=1[CH3:32])[CH2:6]2

Komponenten

3

Edukt 2

HCID 6212ChloroformHCID 99119865,6-Dimethoxy-2-[2,2,4,6,7-pentamethyl-3-(4-methylphenyl)-2,3-dihydro-1-benzofuran-5-yl]isoindoline

Produkt 1

HCID 21961328(-)-5,6-Dimethoxy-2-[2,2,4,6,7-pentamethyl-3-(4-ethylphenyl)-2,3-dihydro-1-benzofuran-5-yl]isoindoline hydrochlorideAusbeute 61 %

Versuchsvorschrift

By using (−)-5,6-dimethoxy-2-[2,2,4,6,7-pentamethyl-3-(4-methylphenyl)-2,3-dihydro-1-benzofuran-5-yl]isoindoline, the title compound was synthesized according to Example 19a. Yield: 61%. Melting point: 173-175° C. [α]D=−44.4° (c=0.501, chloroform)

Quellen und Nachweise

ORD-Eintrag
ord-38274f1abd6e4d0e9a601b10cf8082b4
Quelldatensatz
uspto-grants-2002_11
Patentnummer
US06479536B1

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