Acetic acid, 2-(triphenylphosphoranylidene)-, ethyl ester → HCID 54370741, Verbindung

HRID 1017994Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1017994
[N+:1]([C:4]1[CH:5]=[CH:6][C:7]([CH:10]=O)=[N:8][CH:9]=1)([O-:3])=[O:2].[C:12]([CH:17]=P(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)([O:14][CH2:15][CH3:16])=[O:13]>C1(C)C=CC=CC=1>[CH2:15]([O:14][C:12](=[O:13])[CH:17]=[CH:10][C:7]1[CH:6]=[CH:5][C:4]([N+:1]([O-:3])=[O:2])=[CH:9][N:8]=1)[CH3:16]

Komponenten

4

Edukt 2

HCID 70670Acetic acid, 2-(triphenylphosphoranylidene)-, ethyl esterHCID 151455015-Nitropyridine-2-carbaldehyde

Produkt 1

HCID 54370741HCID 54370741, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel

Versuchsvorschrift

A mixture of 5-nitro-2-pyridinecarbaldehyde (2.85 g prepared according the procedure described in J. Med. Chem. 1992, 35, 3675) and (carbethoxymethylene)triphenylphosphorane (6.0 g) in dry toluene (120 ml) under nitrogen was stirred and heated at reflux for 6 hours. After standing at room temperature overnight the reaction mixture was evaporated. The residue was subjected to flash chromatography on silica gel eluting with dichloromethane to give the title compound (0.8 g) as a yellow solid.

Aufarbeitung

  1. customprepared
  2. temperatureheated
  3. temperatureat reflux for 6 hours
  4. customthe reaction mixture was evaporated

Quellen und Nachweise

ORD-Eintrag
ord-c3dae748d3bf43a6b4d078efe8ca413c
Quelldatensatz
uspto-grants-2002_11
Patentnummer
US06479519B1

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