2-Thiopheneacetic acid → Acetamidomethyl thiolacetate

HRID 1018444Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1018444
[OH:1][CH2:2][NH:3][C:4](=[O:6])[CH3:5].[S:7]1[CH:11]=[CH:10][CH:9]=[C:8]1[CH2:12][C:13](O)=[O:14]>>[S:7]1[CH:11]=[CH:10][CH:9]=[C:8]1[CH2:12][C:13]([O:1][CH2:2][NH:3][C:4](=[O:6])[CH3:5])=[O:14]

Komponenten

3

Edukt 2

HCID 159702-Thiopheneacetic acidHCID 69365Formicin

Produkt 1

HCID 57065091Acetamidomethyl thiolacetateAusbeute 64 %

Versuchsvorschrift

N-(Hydroxymethyl)-acetamide (13.4 g, 0.15 mol) and thiolacetic acid (14.3 g, 0.188 mol) were heated for 3 days at 40° C. The resulting mixture was chromatographed on silica gel (63-200 um, 700 g) with toluene-ethyl acetate 4:1 and 1:1 to give pure crystalline acetamidomethyl thiolacetate (14.2 g, 64%), m.p. 93-94° C.

Aufarbeitung

  1. customThe resulting mixture was chromatographed on silica gel (63-200 um, 700 g) with toluene-ethyl acetate 4:1 and 1:1

Quellen und Nachweise

ORD-Eintrag
ord-6423c437545145188cc82f99b0435964
Quelldatensatz
uspto-grants-2002_11
Patentnummer
US06482818B2

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