Thionyl Chloride → HCID 12011185, Verbindung

HRID 1018504Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1018504
S(Cl)([Cl:3])=O.[Cl:5][C:6]1[CH:21]=[CH:20][CH:19]=[CH:18][C:7]=1[CH2:8][N:9]1[C:13]([CH3:14])=[C:12]([CH3:15])[N:11]=[C:10]1[CH2:16]O>>[Cl:5][C:6]1[CH:21]=[CH:20][CH:19]=[CH:18][C:7]=1[CH2:8][N:9]1[C:13]([CH3:14])=[C:12]([CH3:15])[N:11]=[C:10]1[CH2:16][Cl:3]

Komponenten

3

Edukt 2

HCID 24386Thionyl ChlorideHCID 12011184HCID 12011184, Verbindung

Produkt 1

HCID 12011185HCID 12011185, Verbindung

Reaktionsbedingungen

Temperatur
50 °C

Versuchsvorschrift

To 3 ml of thionyl chloride is added 2.39 g (9.5 mmol) of 1- (2-chlorobenzyl)-4,5 dimethyl-2-hydroxymethylimidazole. The mixture is heated at 50° C. for about 5 min., and the thionyl choride is evaporated in vacuo. The residue is then dissolved in 10 ml of dichloromethane, and subsequently evaporated in vacuo. This is repeated twice to give 1-(2-chlorobenzyl)-4,5-dimethyl-2-chloromethylimidazole (4) as a cream colored foam which is used without further purification.

Aufarbeitung

  1. customthe thionyl choride is evaporated in vacuo
  2. dissolutionThe residue is then dissolved in 10 ml of dichloromethane
  3. customsubsequently evaporated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-329cf04769e3468c870b7ce4572947e3
Quelldatensatz
uspto-grants-2002_11
Patentnummer
US06482844B1

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