(Pyridin-4-yl)boronic acid → HCID 87854766, Verbindung
Reaktionsgleichung
[F:1][C:2]([F:34])([F:33])[C:3]1[CH:4]=[C:5]([CH:26]=[C:27]([C:29]([F:32])([F:31])[F:30])[CH:28]=1)[C:6]([N:8]1[CH2:25][CH2:24][C:11]2([N:15]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)[CH:14]([CH3:22])[NH:13][C:12]2=[O:23])[CH2:10][CH2:9]1)=[O:7].[N:35]1[CH:40]=[CH:39][C:38](B(O)O)=[CH:37][CH:36]=1>>[F:34][C:2]([F:1])([F:33])[C:3]1[CH:4]=[C:5]([CH:26]=[C:27]([C:29]([F:32])([F:31])[F:30])[CH:28]=1)[C:6]([N:8]1[CH2:9][CH2:10][C:11]2([N:15]([C:16]3[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=3)[CH:14]([CH3:22])[N:13]([C:38]3[CH:39]=[CH:40][N:35]=[CH:36][CH:37]=3)[C:12]2=[O:23])[CH2:24][CH2:25]1)=[O:7]Komponenten
3
Versuchsvorschrift
The title compound, MS: m/e=563.2 (M+H+), was prepared in accordance with the general method of example 63 from (rac)-8-(3,5-bis-trifluoromethyl-benzoyl)-2-methyl-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one and pyridine-4-boronic acid.
Quellen und Nachweise
- ORD-Eintrag
- ord-dfd0ce388f844bad901b85dca30291fa
- Quelldatensatz
- uspto-grants-2002_11
- Patentnummer
- US06482829B2