Hydrochloric Acid → 2-Chloro-4,6-di-p-tolyl-1,3,5-triazine

HRID 1019301

Reaktionsgleichung

Reaktionsgleichung von HRID 1019301
[N:1]1[C:8](Cl)=[N:7][C:5](Cl)=[N:4][C:2]=1[Cl:3].[Cl-].[Al+3].[Cl-].[Cl-].Cl.[C:15]1([CH3:21])[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>ClC1C=CC=CC=1Cl>[Cl:3][C:2]1[N:4]=[C:5]([C:18]2[CH:19]=[CH:20][C:15]([CH3:21])=[CH:16][CH:17]=2)[N:7]=[C:8]([C:18]2[CH:19]=[CH:20][C:15]([CH3:21])=[CH:16][CH:17]=2)[N:1]=1

Komponenten

6

Edukt 4

HCID 313Hydrochloric AcidHCID 1140TolueneHCID 7954Cyanuric chlorideHCID 6451240Aluminum(III) Chloride

Produkt 1

HCID 308512-Chloro-4,6-di-p-tolyl-1,3,5-triazine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 72391,2-DichlorobenzeneLösungsmittel

Versuchsvorschrift

To a stirring mixture of 1 eq of cyanuric chloride and 3 eq of aluminum chloride in o-dichlorobenzene at ice bath temperature was added concentrated HCl (13 wt % based on cyanuric chloride). After 10 minutes, 1.9 eq of toluene was added and the reaction mixture was stirred at ice bath temperature for 30 minutes. The cooling bath was removed, the reaction mixture was allowed to warm to room temperature, and stirred for 21 h. HPLC analysis indicated about 95% cyanuric chloride conversion to 2-chloro-4,6-bis(4-methylphenyl)-1,3,5-triazine and the isomer 2-chloro-4-(4-methylphenyl)-6-(2-methylphenyl)-1,3,5-triazine.

Aufarbeitung

  1. customThe cooling bath was removed
  2. stirringstirred for 21 h

Quellen und Nachweise

ORD-Eintrag
ord-4937ccd740b941f9972c40a4442368b7
Quelldatensatz
uspto-grants-2002_11
Patentnummer
US06486316B1

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