Hydrochloric Acid → [2-(2-Chloro-4-nitro-phenyl)-ethyl]-(4-fluoro-benzyl)-amine hydrochloride

Temperatur

0 °C

To a suspension of [2-(2-chloro-4-nitro-phenyl)-ethyl]-(4-fluoro-benzyl)-amine (3.1 g, 10 mmol) in DCM (31 mL) was added 15% HCl in dioxane (2.4 mL, 10 mmol) at 0° C. and the mixture was maintained for 1 hour at 0° C. After completion of salt formation, the volatiles were removed under reduced pressure. A mixture of 4:1 hexane and ethyl acetate (50 mL) was added to the residue and this was stirred for 15 minutes. The solvent was removed by filtration under suction and the solid was dried under reduced pressure to afford crude title product (2.8 g, 80%).

1. customAfter completion of salt formation, the volatiles were removed under reduced pressure
2. additionA mixture of 4:1 hexane and ethyl acetate (50 mL)
3. additionwas added to the residue
4. customThe solvent was removed by filtration under suction
5. customthe solid was dried under reduced pressure

ORD-Eintrag

ord-a75c51ec56a947e98b773e94c92821f9

Quelldatensatz

uspto-grants-2014_05

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US08716287B2