Sodium Azide → 3-Azido-N-methylpropane-1-sulfonamide

Temperatur

100 °C

A mixture of 3-chloro-N-methylpropane-1-sulfonamide (29 mmol), NaN3 (29 mmol) in DMF (50 ml) was stirred at 100° C. for 2 h. The mixture was poured into 40 ml of brine. The mixture was extracted with ether (3×30 ml). The organic layers were combined and washed with 20 ml of brine. The organic layer was dried with Na2SO4, filtered and the filtrate was evaporated. Yield: 4.2 g (90% purity, 81% yield).

1. extractionThe mixture was extracted with ether (3×30 ml)
2. washwashed with 20 ml of brine
3. dry with materialThe organic layer was dried with Na2SO4
4. filtrationfiltered
5. customthe filtrate was evaporated

ORD-Eintrag

ord-7327b5353c674b6295c48d1cd2618630

Quelldatensatz

uspto-grants-2014_05

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US08716293B2