Hydrochloric Acid → HCID 66599641, Verbindung
Reaktionsgleichung
[CH3:1][C:2]1([C:5]([O:7][C:8]2[CH:13]=[CH:12][C:11]([CH:14]([CH2:28][NH:29]C(OC(C)(C)C)=O)[C:15]([NH:17][C:18]3[CH:19]=[C:20]4[C:25](=[CH:26][CH:27]=3)[CH:24]=[N:23][CH:22]=[CH:21]4)=[O:16])=[CH:10][CH:9]=2)=[O:6])[CH2:4][CH2:3]1.[ClH:37]>C(Cl)Cl>[ClH:37].[ClH:37].[CH3:1][C:2]1([C:5]([O:7][C:8]2[CH:9]=[CH:10][C:11]([CH:14]([CH2:28][NH2:29])[C:15]([NH:17][C:18]3[CH:19]=[C:20]4[C:25](=[CH:26][CH:27]=3)[CH:24]=[N:23][CH:22]=[CH:21]4)=[O:16])=[CH:12][CH:13]=2)=[O:6])[CH2:3][CH2:4]1Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
To 4-(3-(tert-butoxycarbonylamino)-1-(isoquinolin-6-ylamino)-1-oxopropan-2-yl)phenyl 1-methylcyclopropanecarboxylate (E11) in CH2Cl2 was added HCl (4N in dioxane) and the solution was stirred for 8-10 h. The solvents were evaporated to give pure 4-(3-amino-1-(isoquinolin-6-ylamino)-1-oxopropan-2-yl)phenyl 1-methylcyclopropanecarboxylate dihydrochloride (E12).