Sodium Hydroxide → 2-(3-(3,4-Dichlorobenzyl)ureido)thiazole-4-carboxylic acid

HRID 1020265Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1020265
[OH-].[Na+].[Cl:3][C:4]1[CH:5]=[C:6]([CH:22]=[CH:23][C:24]=1[Cl:25])[CH2:7][NH:8][C:9](=[O:21])[NH:10][C:11]1[S:12][CH:13]=[C:14]([C:16]([O:18]CC)=[O:17])[N:15]=1>C(O)C>[Cl:3][C:4]1[CH:5]=[C:6]([CH:22]=[CH:23][C:24]=1[Cl:25])[CH2:7][NH:8][C:9](=[O:21])[NH:10][C:11]1[S:12][CH:13]=[C:14]([C:16]([OH:18])=[O:17])[N:15]=1

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 86622748Ethyl 2-(3-(3,4-dichlorobenzyl)ureido)thiazole-4-carboxylate

Produkt 1

HCID 866227642-(3-(3,4-Dichlorobenzyl)ureido)thiazole-4-carboxylic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

Sodium hydroxide (24 mL, 24 mmol, 1N in water) was added to an ethanol (50 mL) solution of ethyl 2-(3-(3,4-dichlorobenzyl)ureido)thiazole-4-carboxylate (Example 38) (1.8 g, 4.8 mmol). The mixture was stirred overnight. The ethanol was removed by evaporation and the aqueous solution was filtered then the filter was washed with water (20 ml). The pH of the filtrate was adjusted to less than three with concentrated HCl. The precipitate was filtered, washed with water and dried to afford 2-(3-(3,4-dichlorobenzyl)ureido)thiazole-4-carboxylic acid.

Aufarbeitung

  1. customThe ethanol was removed by evaporation
  2. filtrationthe aqueous solution was filtered
  3. washthe filter was washed with water (20 ml)
  4. filtrationThe precipitate was filtered
  5. washwashed with water
  6. customdried

Quellen und Nachweise

ORD-Eintrag
ord-c18c43db4e9044b3bab7eb91dc18b865
Quelldatensatz
uspto-grants-2014_05
Patentnummer
US08716320B2

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