Dimethylformamide → 6-Bromo-2-chloroquinoxaline

HRID 1020733Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1020733
[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[NH:8][C:7](=O)[CH:6]=[N:5]2.CN(C=O)C.O=P(Cl)(Cl)[Cl:20]>>[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([Cl:20])[CH:6]=[N:5]2

Komponenten

4

Edukt 3

HCID 6228DimethylformamideHCID 24813Phosphorus oxychlorideHCID 126863946-Bromo-1,2-dihydroquinoxalin-2-one

Produkt 1

HCID 126864086-Bromo-2-chloroquinoxaline

Reaktionsbedingungen

Temperatur
50 °C

Versuchsvorschrift

6-bromoquinoxalin-2(1H)-one (9.0 g, 40 mmol) was dissolved in POCl3 (50 mL) and DMF (2 mL) was added at RT. The mixture was heated at 50° C. for 2 hours. After completion of the reaction it was cooled to RT and was poured slowly into ice cold water. The mixture was stirred for 30 minutes and then filtered to afford crude product.

Aufarbeitung

  1. customAfter completion of the reaction it
  2. temperaturewas cooled to RT
  3. additionwas poured slowly into ice cold water
  4. filtrationfiltered
  5. customto afford crude product

Quellen und Nachweise

ORD-Eintrag
ord-3e5ac592b50a4e9a9d396461501217df
Quelldatensatz
uspto-grants-2014_05
Patentnummer
US08716473B2

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