Ethanol → Ethyl 4-bromobenzene-1-carboximidate

HRID 1020938Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1020938
[Br:1][C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[CH:4][CH:3]=1.[CH3:10][CH2:11][OH:12]>>[CH2:11]([O:12][C:6](=[NH:7])[C:5]1[CH:8]=[CH:9][C:2]([Br:1])=[CH:3][CH:4]=1)[CH3:10]

Komponenten

3

Edukt 2

HCID 702EthanolHCID 12162Benzonitrile, 4-bromo-

Produkt 1

HCID 10466301Ethyl 4-bromobenzene-1-carboximidate

Reaktionsbedingungen

Temperatur
2.5 °C

Versuchsvorschrift

4-Bromo-benzonitrile (5 g) was suspended in absolute EtOH (100 ml) and cooled to 0-5° C. HCl gas was bubbled through, initially vigorously for several minutes and later slowly for 5 hours. The resulting solution was allowed to stir overnight. Most of solvent was removed and the precipitate was filtered, washed with EtOH twice and dried to afford compound 2BM (4.1 g) as white solid.

Aufarbeitung

  1. customHCl gas was bubbled through, initially vigorously for several minutes
  2. customMost of solvent was removed
  3. filtrationthe precipitate was filtered
  4. washwashed with EtOH twice
  5. customdried
  6. customto afford compound 2BM (4.1 g) as white solid

Quellen und Nachweise

ORD-Eintrag
ord-029d5cdefffe43f9b92d527221fa68b0
Quelldatensatz
uspto-grants-2014_05
Patentnummer
US08716483B2

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