Sodium Bicarbonate → HCID 68310238, Verbindung
Reaktionsgleichung
[C:1](=[O:4])([O-])O.[Na+].Cl.Cl.[N:8]1([C:14]2[CH:15]=[C:16]([CH2:20][OH:21])[CH:17]=[CH:18][CH:19]=2)[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]1>C(Cl)(Cl)Cl>[O:4]1[CH2:1][CH2:18][CH:19]([N:11]2[CH2:12][CH2:13][N:8]([C:14]3[CH:15]=[C:16]([CH2:20][OH:21])[CH:17]=[CH:18][CH:19]=3)[CH2:9][CH2:10]2)[CH2:14][CH2:15]1Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
CHCl3 and a saturated aqueous sodium hydrogen carbonate solution were added to [3-(piperazin-1-yl)phenyl]methanol dihydrochloride (240 mg) to carry out liquid separation. The organic layer was dried over MgSO4 and concentrated under reduced pressure. The obtained residue was mixed with dichloromethane (5 ml), and tetrahydro-4H-pyran-4-one (100 mg) and acetic acid (168 mg) were added thereto, followed by stirring at room temperature for 15 minutes. Sodium triacetoxyborohydride (576 mg) was added to the reaction mixture at 0° C., followed by stirring at room temperature for 5 hours. Water and CHCl3 were added to the reaction mixture, and the aqueous layer was adjusted to a pH of 8 to 9 by the addition of a saturated aqueous sodium hydrogen carbonate solution. The organic layer was washed with water, dried over MgSO4, and then concentrated under reduced pressure. The residue was purified by silica gel column chromatography (CHCl3/MeOH) to obtain {3-[4-(tetrahydro-2H-pyran-4-yl)piperazin-1-yl]phenyl}methanol (45 mg).