Sodium Hydroxide → (5-Cyclopropyl-2,4-dimethyl-phenyl)-acetic acid

HRID 1022380Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1022380
C[O:2][C:3](=[O:16])[CH2:4][C:5]1[CH:10]=[C:9]([CH:11]2[CH2:13][CH2:12]2)[C:8]([CH3:14])=[CH:7][C:6]=1[CH3:15].[OH-].[Na+]>CO>[CH:11]1([C:9]2[C:8]([CH3:14])=[CH:7][C:6]([CH3:15])=[C:5]([CH2:4][C:3]([OH:16])=[O:2])[CH:10]=2)[CH2:12][CH2:13]1

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 59614579(5-Cyclopropyl-2,4-dimethyl-phenyl)-acetic acid methyl ester

Produkt 1

HCID 59614593(5-Cyclopropyl-2,4-dimethyl-phenyl)-acetic acidAusbeute 98,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

2.5 g of (5-cyclopropyl-2,4-dimethyl-phenyl)-acetic acid methyl ester in 30 ml of methanol is kept at ice bath temperature and treated with 0.5 g of sodium hydroxide in 5 portions. The reaction mixture is stirred at room temperature for 1.5 hours. The solvent is removed in vacuo, the residue poured into water and extracted with diethyl ether. The combined organic phases are dried with sodium sulfate, filtered and concentrated to afford 2.3 g of (5-cyclopropyl-2,4-dimethyl-phenyl)-acetic acid.

Aufarbeitung

  1. customThe solvent is removed in vacuo
  2. additionthe residue poured into water
  3. extractionextracted with diethyl ether
  4. dry with materialThe combined organic phases are dried with sodium sulfate
  5. filtrationfiltered
  6. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-3be7e45b54cb4d4f957656702393e31e
Quelldatensatz
uspto-grants-2014_05
Patentnummer
US08722578B2

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