tert-butyl (6R,7R)-6-(aminomethyl)-7-(4-chloro-3-fluorophenyl)-1,4-oxazepane-4-carboxylate → N-{[(6S,7R)-7-(4-chloro-3-fluorophenyl)-1,4-oxazepan-6-yl]methyl}-2-(pyridin-2-yloxy)acetamide monohydrochloride

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	tert-butyl (6R,7R)-6-(aminomethyl)-7-(4-chloro-3-fluorophenyl)-1,4-oxazepane-4-carboxylate	HCID 66975002	—
Edukt	2-(2-Pyridyloxy)acetic acid hydrochloride	HCID 66975989	—
Produkt	N-{[(6S,7R)-7-(4-chloro-3-fluorophenyl)-1,4-oxazepan-6-yl]methyl}-2-(pyridin-2-yloxy)acetamide monohydrochloride	HCID 66975109	—

Reaktionsschritte

Using tert-butyl (6R,7R)-6-(aminomethyl)-7-(4-chloro-3-fluorophenyl)-1,4-oxazepane-4-carboxylate and (pyridin-2-yloxy)acetic acid monohydrochloride, and by a method similar to that of Example 39, the title compound was obtained.

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US08722662B2
Quelldatensatz	uspto-grants-2014_05
ORD ID	ord-ab769ca5a3844829884c6867cedabf14
Quellennotiz	uspto-grants-2014_05