Methyl iodide → HCID 178496756, Verbindung
Reaktionsgleichung
[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[C:9]([N:10]3[CH2:15][CH2:14][N:13]([CH2:16][CH2:17][C@H:18]4[CH2:23][CH2:22][C@H:21]([NH:24][C:25](=[O:31])[C@H:26]([OH:30])[CH:27]([CH3:29])[CH3:28])[CH2:20][CH2:19]4)[CH2:12][CH2:11]3)[C:4]=2[O:3][CH2:2]1.[CH3:32]I>>[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[C:9]([N:10]3[CH2:15][CH2:14][N:13]([CH2:16][CH2:17][C@H:18]4[CH2:19][CH2:20][C@H:21]([NH:24][C:25](=[O:31])[C@H:26]([O:30][CH3:32])[CH:27]([CH3:29])[CH3:28])[CH2:22][CH2:23]4)[CH2:12][CH2:11]3)[C:4]=2[O:3][CH2:2]1Komponenten
3
Versuchsvorschrift
The title compound, white solid (6 mg, 50.5%), MS (ISP) m/z=446.3 [(M+H)+], was prepared in accordance with the general method of example 62 from (R)-trans-N-{4-[2-(4-Benzo[1,3]dioxol-4-yl-piperazin-1-yl)-ethyl]-cyclohexyl}-2-hydroxy-3-methyl-butyramide (11.5 mg, 26.6 mmol) and methyl iodide.
Quellen und Nachweise
- ORD-Eintrag
- ord-66537e513bba47819535d2b948b46e7e
- Quelldatensatz
- uspto-grants-2014_05
- Patentnummer
- US08722683B2