Benzoyl isocyanate → 1-Benzoyl-3-{4-[2-(2-methoxy-phenyl)-ethyl]-pyridin-2-yl}-urea
Reaktionsgleichung
[C:1]([N:9]=[C:10]=[O:11])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:12][O:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[CH2:20][CH2:21][C:22]1[CH:27]=[CH:26][N:25]=[C:24]([NH2:28])[CH:23]=1>C(Cl)Cl>[C:1]([NH:9][C:10]([NH:28][C:24]1[CH:23]=[C:22]([CH2:21][CH2:20][C:15]2[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=2[O:13][CH3:12])[CH:27]=[CH:26][N:25]=1)=[O:11])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Reaktionsbedingungen
- Temperatur
- 60 °C
Versuchsvorschrift
Benzoyl isocynate (132 mg, 0.896 mmol) is added to a solution of 4-[2-(2-methoxy-phenyl)-ethyl]-pyridin-2-ylamine (93.0 mg, 0.407 mmol) in CH2Cl2 (4 mL), and the mixture is stirred at 60° C. After 20 hours, the mixture is concentrated to give the crude product, which is used in the next step without purification.