HCID 86762399, Verbindung → HCID 67277260, Verbindung

HRID 1023767Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1023767
[Cl:1][C:2]1[CH:3]=[C:4]([C:12]2[CH:17]=[C:16]([Cl:18])[CH:15]=[CH:14][C:13]=2[O:19][CH2:20][C:21]([O:23]C(C)(C)C)=[O:22])[CH:5]=[CH:6][C:7]=1[S:8]([CH3:11])(=O)=[O:9]>C(O)(C(F)(F)F)=O>[Cl:1][C:2]1[CH:3]=[C:4]([C:12]2[CH:17]=[C:16]([Cl:18])[CH:15]=[CH:14][C:13]=2[O:19][CH2:20][C:21]([OH:23])=[O:22])[CH:5]=[CH:6][C:7]=1[S:8]([CH3:11])=[O:9]

Komponenten

3

Edukt 1

HCID 86762399HCID 86762399, Verbindung

Produkt 1

HCID 67277260HCID 67277260, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6422Trifluoroacetic acidLösungsmittel

Versuchsvorschrift

A solution of the more polar product from Example 2 step d) (35 mg) in TFA (2 ml) was stirred for 24 h. The solvent was removed in vacuo, the mixture was azeotroped with toluene and purified by chromatography (silica, CH2Cl2-MeOH—AcOH as eluent) to give the title compound (22 mg) as a white solid.

Aufarbeitung

  1. customThe solvent was removed in vacuo
  2. customthe mixture was azeotroped with toluene
  3. custompurified by chromatography (silica, CH2Cl2-MeOH—AcOH as eluent)

Quellen und Nachweise

ORD-Eintrag
ord-0298e4be90344ed08c72028118908fee
Quelldatensatz
uspto-grants-2014_05
Patentnummer
US08722741B2

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