1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide → [(4-Iodo-pyridine-2-carbonyl)amino]-acetic acid methyl ester

HRID 1024521Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1024521
[I:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([C:8]([OH:10])=O)[CH:3]=1.CN(C)CCCN=C=NCC.ON1C2C=CC=CC=2N=N1.Cl.[CH3:33][O:34][C:35](=[O:38])[CH2:36][NH2:37]>C(Cl)Cl>[CH3:33][O:34][C:35](=[O:38])[CH2:36][NH:37][C:8]([C:4]1[CH:3]=[C:2]([I:1])[CH:7]=[CH:6][N:5]=1)=[O:10]

Komponenten

6

Edukt 4

HCID 159081-Ethyl-3-(3'-dimethylaminopropyl)carbodiimideHCID 757711-HydroxybenzotriazoleHCID 122755Glycine methyl ester hydrochlorideHCID 8182784-Iodopyridine-2-carboxylic acid

Produkt 1

HCID 59513095[(4-Iodo-pyridine-2-carbonyl)amino]-acetic acid methyl esterAusbeute 44,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a solution of 4-iodo-picolinic acid (1.41 g, 5.66 mmol) in CH2Cl2 (35 mL) at room temperature under N2 is added 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide (EDCI) (1.62 g, 8.49 mmol) and 1-hydroxybenzotriazole (HOBt) (0.077 g, 0.57 mmol). The solution is stirred for 5 minutes and glycine methyl ester hydrochloride (1.07 g, 8.49 mmol) is added and the reaction is stirred 16 hours. The reaction volume is concentrated under reduced pressure and the crude material was partitioned between EtOAc and 1M K2CO3. The aqueous phase is removed and the organic phase washed with H2O, sat. NaCl, dried (MgSO4), filtered and concentrated under reduced pressure to afford a brown oil which is purified over silica (EtOAc:heptane gradient 1:4) to afford 0.805 g (44% yield) of the desired product as a colorless solid. HPLC-MS: m/z 321 [M+H]+.

Aufarbeitung

  1. stirringthe reaction is stirred 16 hours
  2. concentrationThe reaction volume is concentrated under reduced pressure
  3. customthe crude material was partitioned between EtOAc and 1M K2CO3
  4. customThe aqueous phase is removed
  5. washthe organic phase washed with H2O, sat. NaCl
  6. dry with materialdried (MgSO4)
  7. filtrationfiltered
  8. concentrationconcentrated under reduced pressure
  9. customto afford a brown oil which
  10. customis purified over silica (EtOAc:heptane gradient 1:4)

Quellen und Nachweise

ORD-Eintrag
ord-2515c82fc6604accb6923d614c582b39
Quelldatensatz
uspto-grants-2014_05
Patentnummer
US08722895B2

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