Tetrahydrofuran → tert-Butyl {(1S)-1-[(2R)-oxiran-2-yl]-2-phenylethyl}carbamate

Temperatur

25 °C

To a suitable reactor was added 5 (2 g, 4.98 mmol), THF (20 mL), MeOH (20 mL), and K2CO3 (1.5 g, 10.96 mmol) at 20-30° C. under N2. The mixture was stirred at 20-30° C. for 15 hr. The mixture was filtered, and the filtrate was concentrated at 40-50° C. under reduced pressure to yield a pale yellow oil. After being purified by flash column chromatography, 6 was obtained as a white solid in 90% yield.

1. filtrationThe mixture was filtered
2. concentrationthe filtrate was concentrated at 40-50° C. under reduced pressure
3. customto yield a pale yellow oil
4. customAfter being purified by flash column chromatography
5. custom6 was obtained as a white solid in 90% yield

ORD-Eintrag

ord-86b9cc1eedc54bbeb7bff51a2bf76770

Quelldatensatz

uspto-grants-2014_05

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US08722921B2