p-(Trifluoromethoxy)phenol → HCID 86665954, Verbindung
Reaktionsgleichung
[CH2:1]([O:3][C:4](=[O:13])[C:5]1[CH:10]=[CH:9][C:8](Cl)=[N:7][C:6]=1[Cl:12])[CH3:2].[F:14][C:15]([F:25])([F:24])[O:16][C:17]1[CH:22]=[CH:21][C:20]([OH:23])=[CH:19][CH:18]=1>>[CH2:1]([O:3][C:4](=[O:13])[C:5]1[CH:10]=[CH:9][C:8]([O:23][C:20]2[CH:21]=[CH:22][C:17]([O:16][C:15]([F:14])([F:24])[F:25])=[CH:18][CH:19]=2)=[N:7][C:6]=1[Cl:12])[CH3:2]Komponenten
3
Versuchsvorschrift
2,6-dichloronicotinic acid ethyl ester (0.22 g, 0.1 mmol) and 4-trifluoromethoxy-phenol (0.178 g, 0.1 mmol) were coupled using the procedure of Example 17(a) to afford 0.3 g of the required produCt. Percentage purity (LCMS): 64.0%.
Quellen und Nachweise
- ORD-Eintrag
- ord-a36f40e1fb1b4e1dbd607af5a6c56df2
- Quelldatensatz
- uspto-grants-2014_05
- Patentnummer