Methanol → Methyl 3-phenoxypropionate

HRID 1025368

Reaktionsgleichung

Reaktionsgleichung von HRID 1025368
[O:1]([CH2:8][CH2:9][C:10]([OH:12])=[O:11])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:13]O>OS(O)(=O)=O>[O:1]([CH2:8][CH2:9][C:10]([O:12][CH3:13])=[O:11])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Komponenten

4

Edukt 2

HCID 887MethanolHCID 815963-Phenoxypropionic acid

Produkt 1

HCID 347927Methyl 3-phenoxypropionateAusbeute 92,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1118Sulfuric AcidKatalysator

Versuchsvorschrift

3-phenoxypropionic acid (5.0 g, 30 mmol) was dissolved in MeOH (12 mL) and H2SO4 (18 M, 3 drops) was added. The mixture was place in the microwave reactor (T: 140° C., t: 5 min). The solvent was evaporated, the mixture was partitioned in EtOAc (30 mL) and NaOH (2N, 20 mL). The organic phase was dried over MgSO4, filtered, and evaporated to give methyl 3-phenoxypropanoate (5.0 g, 27.7 mmol, 92.5%).

Aufarbeitung

  1. customin the microwave reactor (T: 140° C., t: 5 min)
  2. customThe solvent was evaporated
  3. customthe mixture was partitioned in EtOAc (30 mL)
  4. dry with materialThe organic phase was dried over MgSO4
  5. filtrationfiltered
  6. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-85f1c01ed67c4550afce5f7608219c57
Quelldatensatz
uspto-grants-2014_05
Patentnummer
US08729075B2

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