[4-(2,5-Dichloro-phenoxy)-pyridin-3-yl]-(3,4-dihydro-2H-quinolin-1-yl)-methanone → (2-{[4-(2,5-Dichloro-phenoxy)-pyridine-3-carbonyl]-amino}-4,5-difluoro-phenyl)-carbamic acid tert-butyl ester

HRID 1025842Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1025842
[Cl:1][C:2]1[CH:26]=[CH:25][C:24]([Cl:27])=[CH:23][C:3]=1[O:4][C:5]1[CH:10]=[CH:9][N:8]=[CH:7][C:6]=1[C:11](N1C2C(=CC=CC=2)CCC1)=[O:12].[C:28]([O:32][C:33](=[O:44])[NH:34][C:35]1[CH:40]=[C:39]([F:41])[C:38]([F:42])=[CH:37][C:36]=1[NH2:43])([CH3:31])([CH3:30])[CH3:29]>CCCCCCC.C(OCC)(=O)C>[C:28]([O:32][C:33](=[O:44])[NH:34][C:35]1[CH:40]=[C:39]([F:41])[C:38]([F:42])=[CH:37][C:36]=1[NH:43][C:11]([C:6]1[CH:7]=[N:8][CH:9]=[CH:10][C:5]=1[O:4][C:3]1[CH:23]=[C:24]([Cl:27])[CH:25]=[CH:26][C:2]=1[Cl:1])=[O:12])([CH3:31])([CH3:29])[CH3:30]

Komponenten

4

Edukt 2

HCID 53311781[4-(2,5-Dichloro-phenoxy)-pyridin-3-yl]-(3,4-dihydro-2H-quinolin-1-yl)-methanoneHCID 66619231tert-Butyl (2-amino-4,5-difluorophenyl)carbamate

Produkt 1

HCID 67321135(2-{[4-(2,5-Dichloro-phenoxy)-pyridine-3-carbonyl]-amino}-4,5-difluoro-phenyl)-carbamic acid tert-butyl ester

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 21899848Ethylacetate heptaneLösungsmittel

Versuchsvorschrift

The title compound was prepared in analogy to Example 1, from 4-(2,5-dichloro-phenoxy)-nicotinic acid (Example 1, intermediate) and (2-amino-4,5-difluoro-phenyl)-carbamic acid tert-butyl ester (WO2008000643A1) and using a gradient of n-heptane:ethyl acetate (100:0 to 40:60) for the chromatographic purification. Light yellow solid (73%). MS (ESI): m/z=510.080 [M+H]+.

Aufarbeitung

  1. customfor the chromatographic purification

Quellen und Nachweise

ORD-Eintrag
ord-d6c3d99cc71845e0b405d40ddf122172
Quelldatensatz
uspto-grants-2014_05
Patentnummer
US08729091B2

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