Cesium carbonate → 4-(4-Bromo-2,5-dichlorophenoxy)nicotinic acid

HRID 1025852

Reaktionsgleichung

Reaktionsgleichung von HRID 1025852
Cl[C:2]1[C:7]([C:8]([OH:10])=[O:9])=[CH:6][N:5]=[CH:4][CH:3]=1.[Br:11][C:12]1[C:17]([Cl:18])=[CH:16][C:15]([OH:19])=[C:14]([Cl:20])[CH:13]=1.C(=O)([O-])[O-].[Cs+].[Cs+]>CC1C=CC=CC=1C>[Br:11][C:12]1[C:17]([Cl:18])=[CH:16][C:15]([O:19][C:2]2[C:7]([C:8]([OH:10])=[O:9])=[CH:6][N:5]=[CH:4][CH:3]=2)=[C:14]([Cl:20])[CH:13]=1

Komponenten

5

Edukt 3

HCID 10796Cesium carbonateHCID 160224-Bromo-2,5-dichlorophenolHCID 8182294-Chloronicotinic acid

Produkt 1

HCID 673204804-(4-Bromo-2,5-dichlorophenoxy)nicotinic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 7237O-XyleneLösungsmittel

Reaktionsbedingungen

Temperatur
120 °C

Versuchsvorschrift

To a stirred suspension of 6.0 g (38.08 mmol) 4-chloronicotinic acid (commercially available; CAS RN 10177-29-4) in 200 mL o-xylene were added 10.13 g (41.89 mmol) 4-bromo-2,5-dichlorophenol (commercially available; CAS RN 1940-42-7) and 2.84 g (7.62 mmol) tetrakis-(acetonitrile)-copper hexafluorophosphate (commercially available; CAS RN 64443-05-6). Then 31.31 g (95.20 mmol) cesium carbonate were added and the resulting dark brown suspension as heated to 120° C. for 16 hours. After cooling to room temperature, the sovent was evaporated, the residue dissolved in 1.25 l water, extracted four times with 250 mL ethyl acetate and filtered. The pH of the green filtrate was adjusted to 6 using 25% aqueous hydrochloric acid. The formed precipitate was filtered off to give a first batch of the desired compound. The pH of the filtrate was adjusted to pH 3 using 25% aqueous hydrochloric acid, the suspension stirred for 0.25 hours at room temperature and then kept in the fridge for 64 hours. The suspension was filtered and washed with water to yield another batch of compound. Brown solid (overall yield 5.63 g (41%)). MS (ESI): m/z=363.9 [M+H]+.

Aufarbeitung

  1. temperatureAfter cooling to room temperature
  2. customthe sovent was evaporated
  3. dissolutionthe residue dissolved in 1.25 l water
  4. extractionextracted four times with 250 mL ethyl acetate
  5. filtrationfiltered
  6. filtrationThe formed precipitate was filtered off

Quellen und Nachweise

ORD-Eintrag
ord-6f80d02c8a2b4767bce60a8236b1a180
Quelldatensatz
uspto-grants-2014_05
Patentnummer
US08729091B2

Verknüpfte Notizen

Wird geladen…